Open House 2010

快速病原檢測開發平台
病原檢測晶片與基因晶片線上設計系統

Unique Probe Selector ( U P S ) ,
BMC Bioinformatics (2008), BMC Genomics (2010)

 

USP is a probe design tool for hybridization in low and high throughput experiments. UPS selects unique probe for submitted sequences and evaluates probe-to-target hybridization under a user-defined condition in silico to ensure the high performance of hybridization as well as low possibility of non-specific reaction.

UPS為高專一度探針線上設計工具所設計的探針可用於小規模核酸雜交實驗,如南方墨點法,或微陣列晶片般的大規模雜交實驗,並可應用於環境基因體學、非模式生物基因體之基因表現,與病原體檢測等的小型晶片設計。

 

 

 

新一代藥物標的鑑定系統
複雜生物巨分子交互網路分析平台

Hub Object Analyser , ( Hubba) , Nucleic Acids Research(2008)
 

Hubba is a powerful prediction tool for hub/essential proteins with a user-friendly interface. Hubba can decipher the critical keys inside biochemical pathways and complex network, there will be significant clues to provide candidates for gene knockout and potential drug-targets for developing novel treatment in cancer cells and emerging pathogens. Here we also converted Hubba into cytoHubba, a Cytoscape Plug-in for Hub Object Analysis in Network Biology

Hubba線上分析平台用以分析生物複雜網路交互作用系統中的重要樞紐分子,以圖像化手法呈現重要性來對樞紐蛋白質排名,並顯示這些重要結點之間的關連性,協助辨識疾病細胞內與感染過程中的重要網路次模組,及特定基因群所關連的小網路,提供網路醫學研究與新的治療方法的開發為了利用Cytoscape的輔助與其軟體能見度,cytoscape平台其他plug-in 的協助,我們將hubba變成cytoscape的一個分析模組,稱為cytoHubba 得以提供更多生物學家對龐大的基因網路,採取更精闢、便利的分析,進而提升生物網路分析的準確度

 

最佳化分子親緣關係分析平台

Phylogenetic Reconstruction by Automatic Likelihood Model Selector (PALM) , (PLoS One , 2009)
Automatic phylogenetic analysis with model chosen –free approach according to the ranked score maximum likelihood in various criterion (AIC, AICc, BIC and LnL) and Interactive Tree visualization, 56 substitution models for DNA (JC69, GTR, etc.) and 112 substitution models (JTT, Blosum62, HIVb, etc.) for protein with
paralleled mechanism
自動選擇最佳演化模型化之生物分子親緣關係分析平台,共有56種DNA演化模型及112種蛋白質演化模型,可供本系統同時評估,Compute the Hubba Score 並提供互動式親緣樹檢視介面及平行化運算機制

實驗室電子記錄本

ELECTRIC LABORATORY NOTE BOOK (ELEGANCY,ELN)
Digitalization of Lab notebook from text, gif, raw data, even animations with functions of full text search, backup, sharing and security into server, Notebook and even USB memory stick
將實驗室中所產生的各種紀錄,以電子化方式儲存於網路伺服器/筆記型電腦/USB 隨身碟,並經由瀏覽器方便管理、分享、搜尋、備份、列印,及與研究伙伴線上討論相關問題
 

Two kinds of version will be provided in the future:
1. For group use: Linux-based version
2. For small group/personal use: USB-ELN, windows/ Macbased version

將提供兩種ELN 版本:
1. 大型實驗室群組版本: 相容於Linux 平台環境
2. 中小型實驗室與個人單機版本: USB-ELN, 可相容於微軟視窗/麥金塔 作業環境

 

更多線上研究成果(More Achievements available on Web):

每個系統平台都有動畫短片簡介,協助您快速上手,並利用它來進行您的重要研究。

There are quick views (flash clips) for each system in 3-5 minutes. You can know them in few minutes, then perform them on your own researches.

 

  • PDA Primer design Assistant (PDA), for PCR primer design, NAR2003
聚合?反應核酸引子線上設計平台
 
  • hp-DPI Database of Protein Interactome of Helicobacter pylori, Bioinformatics, 2005
幽門桿菌蛋白質交互作用資料庫
http://dpi.nhri.org.tw/hp
 
 
  • flyDPI Fly-DPI, Database of Protein Interactome of Drosophila melanogaster, BMC bioinformatics, 2006
果蠅蛋白質網路資料庫
http://flydpi.nhri.org.tw
 
  • POWER POWER, phylogenetics web repeater, NAR, 2005
線上生物巨分子親緣關係分析平台
  • myBLAST (web version), a BLAST platform with customized databases and results management, submitted
客製化BLAST序列比對平台,可自行建立資料庫並以條列式方式解析大量結果
 

客製化BLAST 序列比對平行運算高效能平台,可自行建立資料庫並以條列式方式解析大量結果於一般windows平台,並能透過網路分享
 
  • MOLAs MOLAs, Microarray Online Analysis system
基因表現線上分析系統
  • Hunter, A hub-attachment based method to detect functional modules from confidence-scored protein interactions and expression profiles, BMC Bioinformatics, 2010,

http://hub.iis.sinica.edu.tw/Hunter,

以基因表現資料 與蛋白質交互網路來找出具生理功能的蛋白質複合體

  •  Clustering, Assembly of Protein Complexes by Integrating Graph Clusterings, Submitted
複雜生物巨分子網路中蛋白質複合體快速鑑別平台
  • AfterGenbank, Annotation-Feature Extractor from Genbank, Submitted

An updated, value-added data gateway of gene information derived from GenBank database, submitted,  http://aftergenbank.nhri.org.tw,

以圖像化方式擷取特定基因特徵或物種之核酸或蛋白質序列,並提供下載與序列比對,可快速擷取如Microbial 16s rRNA 等大量序列,可供環境基因體(Metagenomics)研究鑑別特定序列群中物種組成所用

 

  • PAGE Penaeus Genome Database, Marine Biotechnology, 2010
Database for Penaeus (Shrimp), a paragon of  database for non-model organism
對蝦類基因體資料庫,為非模式生物資料庫的一個範例
http://sysbio.iis.sinica.edu.tw/page
  
  • HUNTER A hub-attachment based method to detect functional modules from confidence-scored protein interactions and expression profiles, BMC Bioinformatics, 2010
以基因表現資料與蛋白質交互網路來找出具生理功能的蛋白質複合體